# Meta Analysis

> Pool effect sizes across studies only when the studies are genuinely comparable; otherwise plot the individual estimates and state why they cannot be combined. Use whenever an agent wants to produce a single summary number from multiple studies.

- **Type:** Skill
- **Install:** `agentstack add skill-hash-7777-hash-medical-reasearch-agent-skills-meta-analysis`
- **Verified:** Yes — security-reviewed for prompt injection and unsafe behavior
- **Seller:** [Hash-7777](https://agentstack.voostack.com/s/hash-7777)
- **Installs:** 0
- **Category:** [AI & ML](https://agentstack.voostack.com/c/ai-and-ml)
- **Latest version:** 0.1.0
- **License:** MIT
- **Upstream author:** [Hash-7777](https://github.com/Hash-7777)
- **Source:** https://github.com/Hash-7777/Hash-Medical-Reasearch-Agent-Skills/tree/main/skills/meta-analysis

## Install

```sh
agentstack add skill-hash-7777-hash-medical-reasearch-agent-skills-meta-analysis
```

Requires the [AgentStack CLI](https://agentstack.voostack.com/docs/cli). Works with Claude Code, Cursor, and any MCP-compatible agent.

## About

# Meta-Analysis

A pooled number is powerful and dangerous. Done on comparable studies it sharpens the truth; done on studies that measured different things it manufactures a precise-looking lie. The judgment this skill enforces is not "how do I average these" — it is "**should these be averaged at all?**"

## When to use

Whenever the agent is tempted to report one effect size (a risk ratio, an odds ratio, a mean difference, an HR) drawn from more than one study.

## The rule

**Only pool comparable primary studies. When they are not comparable, show them individually and say why.**

Before combining, every study in the pool must share:

1. **Population** — same clinical group, not "adults" vs "elderly with comorbidity" flattened together.
2. **Intervention / exposure** — same drug, comparable dose and route; same exposure definition.
3. **Comparator** — placebo vs active control are different questions; do not mix them into one pool.
4. **Outcome and its measure** — the same endpoint, defined and measured the same way, on the same scale.
5. **Design tier** — do not pool RCTs with observational studies into a single estimate. Report them in separate strata.

If any of these differ materially, **do not pool.** Plot each study's own estimate with its confidence interval (a forest-style layout) and let the reader see the spread.

## Doing the pool responsibly

- **Weight by precision, not by vote.** Larger, tighter studies carry more weight; do not average raw numbers as if each study counted once.
- **Report heterogeneity.** State how much the studies disagree (e.g. an I² and the between-study variance). High heterogeneity is a reason to *stop pooling*, not a footnote.
- **Keep confidence intervals bound to their estimate.** A CI that has drifted from the number it belongs to is a parsing bug that becomes a clinical error. Verify each estimate carries its own interval.
- **Prefer primary studies.** Do not pool a review's summary figure together with the primary trials it already summarizes — that double-counts.

## When you cannot pool

Say it plainly and show the evidence anyway:

```
These 6 studies cannot be pooled: 4 measured 28-day mortality, 2 measured
90-day; comparators differ (placebo vs standard care). Individual estimates:

  Study A (RCT, placebo, 28d)   RR 0.81  [0.70–0.94]
  Study B (RCT, placebo, 28d)   RR 0.88  [0.79–0.98]
  Study C (obs, standard, 90d)  RR 0.72  [0.55–0.95]
  ...
```

A row of honest individual estimates is more useful than one dishonest summary. The skill is knowing the difference.

## Source & license

This open-source skill is cataloged on AgentStack and links to its original source — we do not rehost the code.

- **Author:** [Hash-7777](https://github.com/Hash-7777)
- **Source:** [Hash-7777/Hash-Medical-Reasearch-Agent-Skills](https://github.com/Hash-7777/Hash-Medical-Reasearch-Agent-Skills)
- **License:** MIT

Install and usage instructions live in the source repository linked above.

## Pricing

- **Free** — Free

## Security capabilities

Automated source analysis of v0.1.0 — what this tool can access:

- **Network access:** no
- **Filesystem access:** no
- **Shell / process execution:** no
- **Environment & secrets:** no
- **Dynamic code execution:** no

*"Yes" means the capability is present in the source — more access means more to trust, not that it is unsafe.*


## Versions

- **0.1.0** — security scan: passed — Imported from the upstream source.

## Links

- Listing page: https://agentstack.voostack.com/l/skill-hash-7777-hash-medical-reasearch-agent-skills-meta-analysis
- Seller: https://agentstack.voostack.com/s/hash-7777
- Browse the marketplace: https://agentstack.voostack.com/browse

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