Sdrf:improve

SDRF Specification-Driven Improvement Workflow

You are improving an SDRF file using ONLY specification/template rules.

Do not suggest additions based on:

• Similar datasets in PRIDE
• Literature expectations not encoded in templates
• "Could be more detailed" heuristics
• Personal curator preference

If a change is not justified by template metadata (required/recommended) or TERMS.tsv rules, do not recommend it.

Authoritative Sources (must read)

1. spec/sdrf-proteomics/TERMS.tsv
2. spec/sdrf-proteomics/sdrf-templates/templates.yaml
3. spec/sdrf-proteomics/sdrf-templates/{name}/{version}/{name}.yaml for each template in use

For affinity-proteomics, align with the official template/spec rules:

• Technology template: affinity-proteomics
• Optional experiment child template: olink OR somascan (mutually exclusive)

Step 1: Determine Active Templates

1. Parse comment[sdrf template] columns (NT/VV format).
2. If missing/incomplete, detect from SDRF content and technology type.
3. Confirm template set with the user before proposing edits.

Do not "upgrade" template versions automatically. If a newer version exists, report it as an optional migration task.

Step 2: Build Rule Matrix

Construct an explicit checklist from template YAML files:

• Required columns
• Recommended columns
• Optional columns
• Column validators (values/patterns/ontology)
• Allowed reserved words (not available, not applicable, pooled) via TERMS.tsv flags

For affinity-proteomics specifically, ensure checks include:

• comment[platform] (required)
• comment[panel name] (recommended)
• comment[quantification unit] (optional; values include NPX/RFU in spec)
• comment[normalization method] (optional)
• comment[fraction identifier] (optional)

And for child templates:

• Olink: check Olink-specific required/recommended columns from olink.yaml
• SomaScan: check SomaScan-specific required/recommended columns from somascan.yaml

Step 3: Identify Spec-Backed Improvements

Classify findings into these categories only:

A. Required Fixes (must change)

• Missing required columns from active templates
• Invalid column names not matching SDRF naming patterns
• Values violating template/TERMS validators
• Invalid reserved words per TERMS flags

B. Recommended Fixes (should change)

• Missing columns marked recommended in active templates
• Values that fail recommended validators (warnings)

C. Optional Enhancements (may change)

• Missing optional columns from active templates
• Only include if explicitly present in template metadata

Do not include free-form "quality" recommendations outside A/B/C.

Step 4: Generate Deterministic Report

Report every finding with source traceability:

• Column or value issue
• Severity (required / recommended / optional)
• Exact source rule:
• template file + column definition, or
• TERMS.tsv field (usage/values/allownotavailable/allownotapplicable/allow_pooled)
• Proposed correction

Example format:

Finding: Missing column `comment[panel name]`
Severity: recommended
Source: spec/sdrf-proteomics/sdrf-templates/affinity-proteomics/1.0.0/affinity-proteomics.yaml
Action: Add `comment[panel name]` with panel identifier values.

Step 5: Apply Changes Only with User Approval

Before modifying file contents:

1. Show the exact changes (old -> new)
2. Group by severity (required first)
3. Ask user approval for recommended/optional changes

Required fixes can be applied directly if the user asked to "fix all required issues."

Output Constraints

• No speculative metadata additions
• No PRIDE peer comparison suggestions
• No literature-derived additions unless already required/recommended by templates
• No ontology "more specific child" suggestions unless validator explicitly requires a value constraint

The goal is strict conformance improvement, not curation enrichment.

Source & license

This open-source skill is cataloged on AgentStack and links to its original source — we do not rehost the code.

• Author: bigbio
• Source: bigbio/sdrf-skills
• License: MIT
• Homepage: https://sdrf.quantms.org

Install and usage instructions live in the source repository linked above.